Immune Repertoire Profiling
Mapping the Adaptive Immune System with Next-Generation Sequencing
The adaptive immune system relies on a vast diversity of T-cell receptors (TCRs) and B-cell receptors (BCRs) to recognize and respond to pathogens, tumors, and other antigens. Each unique receptor, defined by V(D)J gene recombination, represents a clonotype that carries critical information about immune history, current activity, and potential responses.
Immune repertoire profiling uses next-generation sequencing (NGS) to decode these receptor sequences at population, single-cell, or paired-chain resolution, providing a detailed view of immune diversity and dynamics.
At AUGenomics, we deliver end-to-end immune repertoire sequencing solutions that combine precision wet-lab workflows with advanced bioinformatics to uncover how the immune system adapts in health, disease, and therapeutic interventions.
Why Immune Repertoire Profiling Matters
The ability to sequence millions of TCR and BCR molecules is revolutionizing how researchers study immunity. These technologies are being used to:
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Discover biomarkers for immunotherapy response and minimal residual disease (MRD).
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Develop next-generation cancer immunotherapies by tracking tumor-infiltrating lymphocytes (TILs).
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Advance vaccine design through mapping of antigen-specific immune responses.
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Study autoimmune mechanisms by identifying autoreactive clones.
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Understand immune aging and plasticity across life stages and diseases.
When paired with single-cell technologies, immune repertoire profiling goes beyond clonality to reveal functional phenotypes, transcriptional states, and antigen specificity, transforming both basic and translational immunology research.
Key Advantages of AUGenomics Immune Repertoire Services
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Comprehensive Coverage: Bulk, single-cell, paired-chain, and custom repertoire sequencing options.
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High-Resolution Clonotype Analysis: Detects rare clones and provides diversity and lineage metrics.
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Functional Integration: Links receptor data with transcriptomics, isotype usage, or multi-omic datasets.
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Customizable Workflows: Supports research in oncology, autoimmunity, infectious disease, and more.
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Cross-Species Support: Human, mouse, rat, NHP, and other models supported.
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Advanced Bioinformatics: Includes clonotype calling, diversity analysis, and publication-ready visualizations.
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Low Input Compatibility: Optimized protocols for challenging samples and small cohorts.
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Collaborative Expertise: Direct consultation from project design to data interpretation.
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Rapid Turnaround: Standard results in 2–3 weeks, with accelerated timelines available.
What We Offer
Our immune repertoire solutions span both bulk and single-cell approaches, supporting TCR and BCR sequencing, paired chain analysis, cytokine profiling, and more.
Explore our full range of immune repertoire profiling services:
Why Choose AUGenomics?
Scientific Precision – Reliable data with high depth and accuracy
Custom Flexibility – Tailored protocols to match your research goals
Fast Turnaround – Streamlined workflows with rapid results
Human Partnership – A responsive, collaborative team invested in your success
From early-stage discovery to clinical or translational research, we’re here to make your sequencing journey faster, easier, and more impactful.
Your Partner in Genomics
Not sure which method is best for your study? Whether you’re comparing whole exome sequencing vs. whole genome sequencing, exploring environmental DNA analysis, or need help with library preparation, we’re happy to guide you through the options.
We believe the best genomics work comes from real partnership—and we’re always ready to talk through your goals, questions, and challenges.
