Gene Panel Sequencing Service
What Is Gene Panel Sequencing Service?
Gene panel sequencing involves selectively sequencing a specific set of genes or genomic regions associated with particular diseases or biological pathways. This targeted NGS approach selectively reads a curated set of genes or genomic regions—ranging from small hotspot assays (5–20 genes) to comprehensive panels (500+ genes). By enriching only 0.1–1% of the genome via hybrid capture or amplicon-based workflows, you achieve ultra-deep coverage (500×–2,000×) with minimal data volume. For example, 1 Gb of panel data yields ~1,000× depth, whereas the same data gives only ~30× WES or ~0.3× WGS. AUGenomics’ customizable panels enable sensitive detection of SNVs, indels, CNVs, and structural variants at ≥ 99% accuracy and ≥ 90% uniformity.
AUGenomics offers fully customizable gene panels, providing precise, cost-effective, and efficient next-generation sequencing (NGS) solutions ideal for targeted research and diagnostic applications.
Advantages of Gene Panel Sequencing
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Maximum Sensitivity: Detect variants down to < 1% allele frequency.
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Data & Cost Efficiency: Save 70–90% on sequencing reagents and storage vs. WES/WGS.
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Customizable Design: Add/remove genes, include noncoding UTRs or promoters.
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High Throughput: Multiplex 96–384 samples per run with dual-index barcoding.
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Quantitative Metrics:
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On-target rate: ≥ 80% (capture) or ≥ 95% (amplicon)
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Coverage uniformity: ≥ 90% of targets at ≥ 0.2× mean depth
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Accuracy: > 99% concordance with orthogonal methods
Gene panel sequencing is highly effective for:
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Oncology research, including cancer-specific mutation detection
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Genetic diagnostics for inherited diseases
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Pharmacogenomic studies for personalized medicine
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Neurological and cardiovascular disease panels
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Immunology and inflammation studies
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Custom research-specific gene panels
Our gene panels are customizable, ensuring comprehensive coverage of critical genomic regions relevant to your specific research or clinical needs.
What is Gene Panel Sequencing Used For?
Gene Panel Sequencing with AUGenomics
Sample Submission
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Accepted Sample Types: Genomic DNA from blood, saliva, FFPE tissue, and buccal swabs
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Input Requirement: 50–100 ng high-quality genomic DNA (lower inputs possible for highly optimized panels)
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Sequencing Recommendations:
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Coverage: Typically 500x–2000x depending on panel complexity and size
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Hybrid-capture or amplicon-based workflows
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Scalable for multiplexing large sample numbers
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Please refer to our Shipping Guidelines for project-specific guidance.
Turnaround Time
Standard gene panel sequencing projects are completed within 7 to 12 business days from receipt of samples. Expedited options are available depending on project scope and sequencing depth.
Frequently Asked Questions (FAQs)
Q: How does a gene panel differ from exome sequencing?
A: Gene panels target specific, carefully selected genomic regions, offering greater sequencing depth and sensitivity for known targets, compared to broader but less focused exome sequencing.
Q: Can AUGenomics assist in designing custom gene panels?
A: Absolutely. We collaborate closely with you to design and validate gene panels tailored specifically to your research goals and clinical needs.
Q: What are the typical panel sizes AUGenomics handles?
A: We offer flexible gene panel sizes from small targeted panels (5–20 genes) to comprehensive panels covering hundreds of genes.
Got more questions? Contact our team and get a free consultation anytime. info@augenomics.com
Glossary of Terms
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Gene Panel: A curated set of genes sequenced simultaneously to detect specific genetic variants
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Hybrid Capture: Method of enriching specific genomic regions using complementary probes
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Amplicon-Based Sequencing: Sequencing method using PCR amplification of target regions
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Coverage: Average number of sequencing reads per nucleotide position in a sample
